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Clinical trials to determine the impacts of using anabolic steroids in human beings began approximately three years later after the first steroid was synthesizedin the laboratory. Because of lack of clinical trials, these results had to be extrapolated to human beings who were not in active steroid use. In the last 20 years, large-scale epidemiologic and epidemiologic studies have been conducted using the most accurate methodologies since the use of standardized methods was widespread in the 1940s under a program of National Strength and Conditioning Training. The objective of these studies is to study outcomes associated with both anabolic ANDrogenic steroids in humans. These studies are also in search of correlations between steroid types. Many of them investigate whether steroids affect different aspects of the body and performance characteristics. The relationship between steroid use and the different aspects of cardiovascular and anabolic steroids is not clear, although most studies have reported correlations of + .6- to + 1.1- standard deviations. Steroid Types and Exercise Interventions There are several theories as to the effect different types of steroid will have on endurance and muscular endurance in humans. Anabolic steroids can stimulate the production of nitric oxide which is also known as endothelial nitric oxide synthase (eNOS). This is an essential enzyme of the endothelial system as cells use these endothelium to absorb fluid from the blood. Nitric oxide (NO) is also responsible for lowering blood pressure, thus making exercise more palatable, and lowering stress. Anabolic steroids are usually stored in the muscle in the form of glucocorticoids to help control muscle activity and facilitate fat utilization as a byproduct. Although glucocorticoids are usually used to stimulate muscle, certain types of steroids do not stimulate the production of NO, they act on enzymes called NO synthases that convert NO into NO, thus increasing levels of NO. Because of their effects on NO production, anabolic steroids suppress the growth of certain muscle tissue called myofibrils. In the case of a muscle fiber, when anabolic steroids bind to the myofibrils proteins called myofibrillar protein actin are also broken down, leaving the fibers relatively intact. This reduces the work of contraction, while the reduction of contraction helps to stimulate the contractile capacity of the fiber. By contrast, the effects of anabolic steroids on myofibrils in another group of fibers like myofibrillar connective tissue are not fully understood. The growth and development that is normally required to accommodate the exercise demands of an active athlete, while the effects of anabolic steroid- Similar articles: